Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Ankle fracture
ADR ID BADD_A00246
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.04      Bone and joint injuries
12.04.01      Limb fractures and dislocations
12.04.01.005      Ankle fracture
15      Musculoskeletal and connective tissue disorders
15.08      Fractures
15.08.03      Limb fractures
15.08.03.005      Ankle fracture
Description A finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot. [CTCAE] Fractures of any of the bones of the ANKLE. [MeSH]
MedDRA Code 10002544
MeSH ID D064386; D064386; D064386
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Ankle fracture | Bimalleolar fracture, closed | Bimalleolar fracture, open | Broken ankle | Fracture of ankle | Fracture of ankle, unspecified, closed | Fracture of lateral malleolus, closed | Fracture of lateral malleolus, open | Fracture of medial malleolus, closed | Fracture of medial malleolus, open | Pott's fracture | Trimalleolar fracture, closed | Trimalleolar fracture, open | Unspecified fracture of ankle, closed | Unspecified fracture of ankle, open | Malleolar fracture | Bimalleolar fracture | Ankle Fractures | Ankle Fracture | Fracture, Ankle | Fractures, Ankle | Lateral Malleolus Fractures | Fracture, Lateral Malleolus | Fractures, Lateral Malleolus | Lateral Malleolus Fracture | Malleolus Fracture, Lateral | Malleolus Fractures, Lateral | Trimalleolar Fractures | Fracture, Trimalleolar | Fractures, Trimalleolar | Trimalleolar Fracture | Trimalleolar Ankle Fractures | Ankle Fracture, Trimalleolar | Ankle Fractures, Trimalleolar | Fracture, Trimalleolar Ankle | Fractures, Trimalleolar Ankle | Trimalleolar Ankle Fracture | Medial Malleolus Fractures | Fracture, Medial Malleolus | Fractures, Medial Malleolus | Malleolus Fracture, Medial | Malleolus Fractures, Medial | Medial Malleolus Fracture | Posterior Malleolus Fractures | Fracture, Posterior Malleolus | Fractures, Posterior Malleolus | Malleolus Fracture, Posterior | Malleolus Fractures, Posterior | Posterior Malleolus Fracture | Bimalleolar Fractures | Bimalleolar Fracture | Fracture, Bimalleolar | Fractures, Bimalleolar | Bimalleolar Equivalent Ankle Fractures | Bimalleolar Equivalent Fractures | Bimalleolar Equivalent Fracture | Equivalent Fracture, Bimalleolar | Equivalent Fractures, Bimalleolar | Fracture, Bimalleolar Equivalent | Fractures, Bimalleolar Equivalent | Bimalleolar Ankle Fractures | Ankle Fracture, Bimalleolar | Ankle Fractures, Bimalleolar | Bimalleolar Ankle Fracture | Fracture, Bimalleolar Ankle | Fractures, Bimalleolar Ankle
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00044Adefovir dipivoxil0.002893%
BADD_D00066Alendronic acid0.006668%
BADD_D00100Ambrisentan--
BADD_D00121Amlodipine0.000031%
BADD_D00151Apixaban--
BADD_D00156Apremilast--
BADD_D00165Aripiprazole0.000954%
BADD_D00194Azacitidine0.000533%
BADD_D00209Baclofen0.000337%
BADD_D00277Bisoprolol0.002013%
BADD_D00285Bosentan0.002683%
BADD_D00310Buprenorphine0.001859%
BADD_D00349Capecitabine--
BADD_D00374Carvedilol0.000246%
BADD_D00511Clozapine0.156934%
BADD_D00535Crizotinib0.000533%
BADD_D00564Dabigatran etexilate0.005802%
BADD_D00574Dalfampridine0.011764%
BADD_D00680Dimethyl fumarate0.017420%
BADD_D00732Droxidopa0.001484%
BADD_D00734Duloxetine0.000198%
BADD_D00775Enzalutamide--
BADD_D00794Ergocalciferol0.000102%
BADD_D00809Escitalopram--
BADD_D00852Etonogestrel--
BADD_D00898Finasteride0.000748%
BADD_D00979Furosemide0.000063%
BADD_D01119Ibrutinib--
BADD_D01135Iloprost0.000371%
BADD_D01136Imatinib--
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